Structure
NS1652, inhibitor
NS1652
Purity
98.00%
Synonyms
NS1652; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 4.9mg/mL (15.11mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Boiling Point
355 degree C
Formula
C15H11F3N2O3
SMILES
OC(=O)c1ccccc1NC(=O)Nc1cccc(c1)C(F)(F)F
CAS Number
1566-81-0
Target & IC50
chloride channel, human and mouse red blood cell: ic50 1.6uM
In Vitro
In mice, NS1652 (50mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90%[2].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for NS1652, inhibitor
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6uM in human and mouse red blood cells.
Product Categories/Family for NS1652, inhibitor
References
Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.
Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS165Blood. 2000 Mar 1;95(5):1842-8.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8.
Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS165Blood. 2000 Mar 1;95(5):1842-8.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8.
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Product Notes
The NS1652 (Catalog #AAA5755278) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NS1652, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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