Structure
Nef-IN-B9, Inhibitor
Nef-IN-B9
Purity
>98% (HPLC)
Synonyms
Nef-IN-B9; Nef inhibitor B9; inhibitor
Purity/Purification
>98% (HPLC)
Target
HIV
Receptor
HIV
Chemical Name
(E)-4-((3-chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide
Molecular Formula
C16H11ClN6O3S
CAS Number
1473404-51-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Nef-IN-B9, inhibitor
Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8uM, while the activity against Hck alone is >20uM; also showes weak activity against other Src-family members with IC50 of >20uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79nM.
Product Categories/Family for Nef-IN-B9, inhibitor
References
1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24; 20 (1):82-91.
Similar Products
Product Notes
The Nef-IN-B9 (Catalog #AAA3602024) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nef-IN-B9, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
