MT47-100, Inhibitor
MT47-100
Purity
>98% (HPLC)
Synonyms
MT47-100; MT 47-100; inhibitor
Purity/Purification
>98% (HPLC)
Target
AMPK
Receptor
AMPK
Chemical Name
2, 4-dihydroxy-6-(2'-hydroxy-[1, 1'-biphenyl]-4-yl)quinoline-3-carbonitrile
SMILES
C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CC4=C(C=C3)NC(=O)C(=C4O)C#N)O
Molecular Formula
C22H14N2O3
CAS Number
1179347-23-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for MT47-100, inhibitor
A novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the beta1 or beta2 isoform, respectively; maximally activates alpha1beta1gamma1 approximately 2.5-fold with half-maximal activation Ka of 3.7uM and activates all AMPKbeta1 complexes regardless alpha or gamma isoforms; directly inhibits AMPKbeta2 complexes independently of alpha or gamma isoforms with Ki of 24.8uM, this inhibition is dependent on the beta2 carbohydrate-binding module (CBM) and independent of beta2-Ser108 phosphorylation; augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a beta2-dependent mechanism.
Product Categories/Family for MT47-100, inhibitor
References
1. Scott JW, et al. Chem Biol. 2015 Jun 18; 22 (6):705-11.
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Product Notes
The MT47-100 (Catalog #AAA3600607) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MT47-100, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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