Structure
MS-417, Inhibitor
MS-417
Purity
>98% (HPLC)
Synonyms
MS-417; GTPL-7512; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
Ethanol: 50mg/mL (120.51mM)
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
Methyl 2-[(6S, Z)-4-(4-chlorophenyl)-2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl]acetate
SMILES
CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC)C4=CC=C(C=C4)Cl)C
Molecular Formula
C20H19ClN4O2S
CAS Number
916489-36-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MS-417, inhibitor
MS-417 (GTPL-7512) is a highly specific BET bromodomain inhibitor that binds to BRD4-BD1 and BRD4 BD2 with Kd of 36.1uM and 25.4uM respectively; shows 100-200-fold weaker affinity for CBP, BRD7, or BPTF, and no binding affinity for many other bromodomains; blocks BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV; ameliorates inflammation and kidney injury in HIV-1 transgenic mice.
Product Categories/Family for MS-417, inhibitor
References
1. Zhang G, et al. J Biol Chem. 2012 Aug 17; 287 (34):28840-51.
2. Boehm D, et al. Cell Cycle. 2013 Feb 1; 12 (3):452-62.
2. Boehm D, et al. Cell Cycle. 2013 Feb 1; 12 (3):452-62.
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Product Notes
The MS-417 (Catalog #AAA3606577) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MS-417, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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