Structure
JQ1, Inhibitor
JQ1
Purity
>98% (HPLC)
Synonyms
JQ1; JQ-1; (+)-JQ-1; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=45mg/mL
Target
Bromodomain
Receptor
BRD4 (1); BRD4 (2)
Chemical Name
6H-Thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2, 3, 9-trimethyl-, 1, 1-dimethylethyl ester, (6S)
SMILES
O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
Molecular Formula
C23H25ClN4O2S
CAS Number
1268524-70-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for JQ1, inhibitor
(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77nM/33nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treatednMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.
Product Categories/Family for JQ1, inhibitor
References
1. Filippakopoulos P, et al. Nature. 2010 Dec 23; 468 (7327):1067-73.
2. Matzuk MM, et al. Cell. 2012 Aug 17; 150 (4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct; 31 (10):2037-2047.
4. Tgel L, et al. Mol Cancer Ther. 2016 Jun; 15 (6):1217-26.
2. Matzuk MM, et al. Cell. 2012 Aug 17; 150 (4):673-84.
3. Peirs S, et al. Leukemia. 2017 Oct; 31 (10):2037-2047.
4. Tgel L, et al. Mol Cancer Ther. 2016 Jun; 15 (6):1217-26.
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Product Notes
The JQ1 (Catalog #AAA3601126) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JQ1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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