MRT67307 HCl, Inhibitor | MRT67307, inhibitor
MRT67307 HCl
Purity
98.00%
Synonyms
MRT67307 HCl; MRT67307; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: >=23.25mg/mL
Ethanol: >=30.67mg/mL
H2O: >=52.5mg/mL with gentle warming
H2O: >=52.5mg/mL with gentle warming
Ethanol: >=30.67mg/mL
DMSO: >=23.25mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Ethanol: >=30.67mg/mL
H2O: >=52.5mg/mL with gentle warming
H2O: >=52.5mg/mL with gentle warming
Ethanol: >=30.67mg/mL
DMSO: >=23.25mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H36N6O2- xHCl
SMILES
O=C(C1CCC1)NCCCNC2=NC(NC3=CC(CN4CCOCC4)=CC=C3)=NC=C2C5CC5.[xHCl]
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for MRT67307, inhibitor
MRT67307 is an inhibitor for TBK1, IKKepsilon, MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM, respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.
SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and other anti-inflammatory molecules. IKKepsilon and TBK-1 mediate the phosphorylation of interferon regulatory factor 3 (IRF3). MARK1 is a Serine/threonine-protein kinase.
In macrophages, MRT67307 prevented the production of IFNbeta and the phosphorylation of IRF3 without suppressing the activation of NF-kappaB, which showed that MRT67307 blocked the induction of Pellino 1 through inhibiting TBK1/IKKepsilon kinase activity [1] [3]. Also, MRT67307 completely blocked the TBK1- or IKKepsilon-induced decrease in the mobility of Pellino 1 [3]. Exposed macrophages to MRT67307 increased the levels of the anti-inflammatory cytokines IL-1ra and IL-10 and decreased the levels of proinflammatory cytokines (such as IL-6, IL-12, and TNF) in response to bacterial lipopolysaccharide (LPS) [4].
SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and other anti-inflammatory molecules. IKKepsilon and TBK-1 mediate the phosphorylation of interferon regulatory factor 3 (IRF3). MARK1 is a Serine/threonine-protein kinase.
In macrophages, MRT67307 prevented the production of IFNbeta and the phosphorylation of IRF3 without suppressing the activation of NF-kappaB, which showed that MRT67307 blocked the induction of Pellino 1 through inhibiting TBK1/IKKepsilon kinase activity [1] [3]. Also, MRT67307 completely blocked the TBK1- or IKKepsilon-induced decrease in the mobility of Pellino 1 [3]. Exposed macrophages to MRT67307 increased the levels of the anti-inflammatory cytokines IL-1ra and IL-10 and decreased the levels of proinflammatory cytokines (such as IL-6, IL-12, and TNF) in response to bacterial lipopolysaccharide (LPS) [4].
Product Categories/Family for MRT67307, inhibitor
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Product Notes
The MRT67307 (Catalog #AAA5757503) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MRT67307 HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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