Structure
miR-21 inhibitor 37, Inhibitor
miR-21 inhibitor 37
Purity
>98% (HPLC)
Synonyms
miR-21 inhibitor 37; inhibitor
Purity/Purification
>98% (HPLC)
Target
MicroRNA
Receptor
MicroRNA
Chemical Name
(E)-1-(3-(5-amino-4-(3-(4-(prop-2-yn-1-yloxy)phenyl)-1, 2, 4-oxadiazol-5-yl)-1H-1, 2, 3-triazol-1-yl)phenyl)ethan-1-one oxime
Molecular Formula
C21H17N7O3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for miR-21 inhibitor 37, inhibitor
miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels in A498 RCC cells, sensitizes cells to topotecan-induced apoptosis.
Product Categories/Family for miR-21 inhibitor 37, inhibitor
References
1. Naro Y, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.7b01891.
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Product Notes
The miR-21 inhibitor 37 (Catalog #AAA3607035) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "miR-21 inhibitor 37, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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