Maytansinol, Inhibitor

Maytansinol

Cat. Num. AAA5755165

• Purity: 98.00%
• Synonyms: Maytansinol; Ansamitocin P-0; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 35mg/mL (61.94mM); (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C28H37ClN2O8
• SMILES: C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1
• CAS Number: 57103-68-1
• Target & IC50: Maytansinoids
• In Vitro: Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for Maytansinol, inhibitor

Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.

Product Categories/Family for Maytansinol, inhibitor

Metabolism; PPAR; Others

References

Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.