Lys05, inhibitor
Lys05 trihydrochloride
Purity
99.1%
Synonyms
Lys05; Lys05 trihydrochloride; inhibitor
Purity/Purification
99.1%
Form/Format
POWDER
CAS
1391426-24-6
Formula
C23H26Cl5N5
Pathways
Autophagy
Target
HT-29
Smiles
c12c(cc(cc1)Cl)nccc2NCCN(CCNc1ccnc2c1ccc(c2)Cl)C.Cl.Cl.Cl
Receptor
lysosomal autophagy (1205Lu); lysosomal autophagy (c8161); lysosomal autophagy (HT-29); lysosomal autophagy (LN229)
Bioactivity
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
Solubility
Water: 6.4 mg/mL (Need ultrasonic)
Solubility Note
For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.
Preparation and Storage
For 3 years at -20 degree C (powder)
For 2 years -80 degree C in solvent.
For 2 years -80 degree C in solvent.
References
1. McAfee Q, et al. Proc Natl Acad Sci U S A. 2012 May 22; 109 (21):8253-8.
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Product Notes
The Lys05 (Catalog #AAA579571) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lys05, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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