Structure
Lys05, Inhibitor
Lys05
Purity
>98% (HPLC)
Synonyms
Lys05; Lys-05; Lys 05; Lys01 trihydrochloride; PS-1001; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.4mg/mL (Need Ultrasonic
Water: 3mg/mL (5.5mM)
Ethanol: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Water: 3mg/mL (5.5mM)
Ethanol: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Autophagy
Receptor
lysosomalautophagy (1205Lu); lysosomalautophagy (c8161); lysosomalautophagy (HT-29); lysosomalautophagy (LN229)
Chemical Name
N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1, 2-ethanediamine trihydrochloride
SMILES
CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C23H26Cl5N5
CAS Number
1391426-24-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Lys05, inhibitor
Lys05 (Lys01 trihydrochloride, PS-1001) is the water-soluble salt of Lys01, is a 10-fold more potent lysosomal autophagy inhibitor than hydroxychloroquine (HCQ); shows IC50 values of 3.6, 3.8, 6 and 7.9uM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay; more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth; enhances sunitinib-mediated suppression of clear cell ovarian carcinoma (CCOC) cell viability.
Product Categories/Family for Lys05, inhibitor
References
1. McAfee Q, et al. Proc Natl Acad Sci U S A. 2012 May 22; 109 (21):8253-8.
2. Amaravadi RK, et al. Autophagy. 2012 Sep; 8 (9):1383-4.
3. DeVorkin L, et al. Mol Cancer Res. 2017 Mar; 15 (3):250-258.
4. Ndoye A, et al. Cancer Res. 2017 Nov 1; 77 (21):5873-5885.
2. Amaravadi RK, et al. Autophagy. 2012 Sep; 8 (9):1383-4.
3. DeVorkin L, et al. Mol Cancer Res. 2017 Mar; 15 (3):250-258.
4. Ndoye A, et al. Cancer Res. 2017 Nov 1; 77 (21):5873-5885.
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Product Notes
The Lys05 (Catalog #AAA3601622) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lys05, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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