Testing Data
LY2603618, inhibitor
LY2603618 (IC-83)
Synonyms
LY2603618; LY2603618 (IC-83); inhibitor
Solubility
DMSO >=21 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C18H22BrN5O3
CAS Number
911222-45-2
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for LY2603618, inhibitor
LY2603618 (IC-83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY2603618 (IC-83) binds to and inhibits the activity of chk1, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk1, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk1 is overexpressed by a variety of cancer cell types. [1][2]
Product Categories/Family for LY2603618, inhibitor
References
New insights into checkpoint kinase 1 in the DNA damage response signaling network. Dai Y et al. Clin Cancer Res. 2010 Jan 15; 16(2):376-83. http://www.springer.com/biomed/cancer/book/978-1-60761-177-6 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Similar Products
Product Notes
The LY2603618 (Catalog #AAA8506277) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2603618, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
