Structure
Lethal toxin inhibitor DN1, Inhibitor
Lethal toxin inhibitor DN1
Purity
>98% (HPLC)
Synonyms
Lethal toxin inhibitor DN1; inhibitor
Purity/Purification
>98% (HPLC)
Target
Antibacterial
Receptor
Antibacterial
Chemical Name
4-fluoro- N'-[1-(2-pyridinyl)ethylidene]benzohydrazide
SMILES
CC(=NNC(=O)C1=CC=C(C=C1)F)C2=CC=CC=N2
Molecular Formula
C14H12FN3O
CAS Number
325990-63-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Lethal toxin inhibitor DN1, inhibitor
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
Product Categories/Family for Lethal toxin inhibitor DN1, inhibitor
References
1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231.
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Product Notes
The Lethal toxin inhibitor DN1 (Catalog #AAA3604057) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lethal toxin inhibitor DN1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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