Structure
LDC000067, Inhibitor
LDC000067
Purity
>98% (HPLC)
Synonyms
LDC000067; LDC-000067; LDC 000067; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=47mg/mL (126.88mM)
Target
HMG-CoA Reductase
Receptor
CDK1; CDK2; CDK4; CDK6; CDK9
Chemical Name
6-(6-(1-Methyl-1H-pyrazol-4-yl)-[1, 2, 4]triazolo[4, 3-b]pyridazin-3-ylthio)quinoline
SMILES
COc1ccccc1c1cc(ncn1)Nc1cccc(c1)CS(=O)(=O)N
Molecular Formula
C18H18N4O3S
CAS Number
1073485-20-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LDC000067, inhibitor
LDC000067 is a potent and selective CDK9 inhibitor. LDC000067 inhibited in vitro transcription in an ATP-competitive and dose-dependent manner. Gene expression profiling of cells treated with LDC000067 demonstrated a selective reduction of short-lived mRNAs, including important regulators of proliferation and apoptosis. Analysis of de novoRNA synthesis suggested a wide ranging positive role of CDK9. At the molecular and cellular level, LDC000067 reproduced effects characteristic of CDK9 inhibition such as enhanced pausing of RNA polymerase II on genes and, most importantly, induction of apoptosis in cancer cells.
Product Categories/Family for LDC000067, inhibitor
References
1. Albert TK, et al. Br J Pharmacol. 2014, 171 (1), 55-68.
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Product Notes
The LDC000067 (Catalog #AAA3607132) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LDC000067, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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