L-asarinin, Inhibitor

L-asarinin

Cat. Num. AAA5758070

• Purity: 98.00%
• Synonyms: L-asarinin; (-)-Episesamin; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: Soluble; Chloroform: Soluble; Dichloromethane: Soluble; Ethyl Acetate: Soluble; Acetone: Soluble; Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C20H18O6
• SMILES: C5O[C@@H](c1ccc2OCOc2c1)[C@H]6CO[C@H](c3ccc4OCOc4c3)[C@@H]56
• CAS Number: 133-05-1
• Target & IC50: Others
• Kinase Assay: Samples containing either URB602 (300uM), MGL (1.4 pM), or both URB602 and MGL are incubated at 37 degree C for 30 min in assay buffer. At various time points, the reaction is stopped with an equal volume of ice-cold methanol and directly analyzed in positive ionization mode by LC/MS. A SB-CN column (150x2.1mM i.d., 5uM) eluted is used with a linear gradient of methanol in water containing 0.25% acetic acid and 5mM ammonium acetate (from 60% to 100% of methanol in 8 min) at a flow rate of 0.5mL/min with column temperature at 50 degree C. Capillary voltage is set at 4 kV and fragmentor voltage is 100V. Nebulizer pressure is set at 60psi. N2 is used as drying gas at a flow rate of 13 liters/min and a temperature of 350 degree C. ESI is in the positive mode and a full scan spectrum is acquired from m/z 100 to 600. Extracted ion chromatograms are used to quantify URB602 ([M+H]+, m/z 296)[2].
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for L-asarinin, inhibitor

Asarinin reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft heart survival.

References

Gu J., et al. The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation. Transplant Proc. 2015 Mar;47(2):545-8.
Gu J., et al. The effect of Asarinin on Toll-like pathway in rats after cardiac allograft implantation. Transplant Proc. 2015 Mar;47(2):545-8.
Bogurcu N., et al. ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. Biochem Biophys Res Commun. 2011 Jun 17;409(4):738-44.
Bogurcu N., et al. ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. Biochem Biophys Res Commun. 2011 Jun 17;409(4):738-44.