Chemical Structure
Ki16425, Inhibitor
Ki16425
Purity
>98%
Synonyms
Ki16425; Ki 16425; Ki-16425; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 21.05 mL (1 mg); 105.26 mL (5 mg); 210.53mL (10 mg)
0.5 mM: 4.21 mL (1 mg); 21.05 mL (5 mg); 42.11 mL (10 mg)
1 mM: 2.11 mL (1 mg); 10.53 mL (5 mg); 21.05 mL (10 mg)
5 mM: 0.42 mL (1 mg); 2.11 mL (5 mg); 4.21 mL (10 mg) (varies by lot)
0.5 mM: 4.21 mL (1 mg); 21.05 mL (5 mg); 42.11 mL (10 mg)
1 mM: 2.11 mL (1 mg); 10.53 mL (5 mg); 21.05 mL (10 mg)
5 mM: 0.42 mL (1 mg); 2.11 mL (5 mg); 4.21 mL (10 mg) (varies by lot)
CAS Number
355025-24-0
Formula
C23H23ClN2O5S
SMILES
CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
Actions
Antagonist
In Vivo Solvent
5% DMSO/95% Corn oil
Solubility (DMSO)
95 mg/mL (200.01 mM)
Solubility (Ethanol)
95 mg/mL (200.01 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for Ki16425, inhibitor
Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3 and exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively.
References
Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
Similar Products
Product Notes
The Ki16425 (Catalog #AAA384981) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ki16425, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
