Structure
ITI214 free base, Inhibitor
ITI214 free base
Purity
>98% (HPLC)
Synonyms
ITI214 free base; ITI-214 free base; ITI 214 free base; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PDE
Receptor
PDE
Chemical Name
Cyclopent[4, 5]imidazo[1, 2-a]pyrazolo[4, 3-e]pyrimidin-4(2H)-one, 2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5, 6a, 7, 8, 9, 9a-hexahydro-5-methyl-3-(phenylamino)-, (6aR, 9aS)
SMILES
CN1C(=O)C2=C(N(N=C2N3C1=NC4C3CCC4)CC5=CC=C(C=C5)C6=NC(=CC=C6)F)NC7=CC=CC=C7
Molecular Formula
C29H26FN7O
CAS Number
1160521-50-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ITI214 free base, inhibitor
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms; improves the memory processes of acquisition, consolidation, and retrieval across a broad dose range (0.1-10mg/kg, po) without disrupting the antipsychotic-like activity of a clinical antipsychotic medication, shows potential for schizophrenia and Alzheimer's disease, movement disorders, attention deficit and hyperactivity disorders, and other central nervous system (CNS) and non-CNS disorders. Parkinson Disease Phase 2 Clinical
Product Categories/Family for ITI214 free base, inhibitor
References
1. Li P, et al. J Med Chem. 2016 Feb 11; 59 (3):1149-64.
2. Snyder GL, et al. Psychopharmacology (Berl). 2016 Sep; 233 (17):3113-24.
2. Snyder GL, et al. Psychopharmacology (Berl). 2016 Sep; 233 (17):3113-24.
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Product Notes
The ITI214 free base (Catalog #AAA3600556) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ITI214 free base, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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