Structure
HT-0712, Inhibitor
HT-0712
Purity
>98% (HPLC)
Synonyms
HT-0712; IPL-455903; inhibitor
Purity/Purification
>98% (HPLC)
Target
PDE
Receptor
PDE
Chemical Name
(3S, 5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one
SMILES
O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4
Molecular Formula
C25H31NO3
CAS Number
617720-02-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for HT-0712, inhibitor
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A; facilitates expression of a CRE-luciferase reporter gene and expression of the CREB target-gene somatostatin in SK-N-MC neuroblastoma cells, abolishes the long-term memory defect of CBP+/- mice, enhances long-term memory formation in normal young mice at brain concentrations similar to those found to increase CRE-mediated gene expression in hippocampal neurons. Alzheimer Disease Phase 2 Clinical
Product Categories/Family for HT-0712, inhibitor
References
1. Peters M, et al. Neuropsychopharmacology. 2014 Dec; 39 (13):2938-48.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec; 21 (6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2; 100 (18):10518-22.
2. MacDonald E, et al. Neurorehabil Neural Repair. 2007 Nov-Dec; 21 (6):486-96.
3. Bourtchouladze R, et al. Proc Natl Acad Sci U S A. 2003 Sep 2; 100 (18):10518-22.
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Product Notes
The HT-0712 (Catalog #AAA3605334) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HT-0712, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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