Structure
Hippuristanol, Inhibitor
Hippuristanol
Purity
>98% (HPLC)
Synonyms
Hippuristanol; inhibitor
Purity/Purification
>98% (HPLC)
Target
eIF
Receptor
eIF
Chemical Name
(3R, 5S, 11S, 20R, 22S, 24S)-24-Methyl-22, 25-epoxyfurostan-3, 11, 20-triol
SMILES
[H][C@]1(O[C@@](C[C@H](C)C2(C)C)(O2)[C@@]3(O)C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@H](O)CC[C@]6(C)[C@@]5([H])[C@@H](O)C[C@]4(C)[C@]13[H]
Molecular Formula
C28H46O5
CAS Number
80442-78-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Hippuristanol, inhibitor
Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis; also reduces the expression of cyclin D2, CDK2, CDK4, CDK6 and prosurvival XIAP and Mcl-1 proteins; significantly inhibits the growth and invasion of PEL cells in mice.
Product Categories/Family for Hippuristanol, inhibitor
References
1. Cencic R, et al. Translation (Austin). 2016 Jan 4; 4 (1):e1137381.
2. Somaiah R, et al. J Med Chem. 2014 Mar 27; 57 (6):2511-23.
3. Ishikawa C, et al. Mar Drugs. 2013 Sep 6; 11 (9):3410-24.
2. Somaiah R, et al. J Med Chem. 2014 Mar 27; 57 (6):2511-23.
3. Ishikawa C, et al. Mar Drugs. 2013 Sep 6; 11 (9):3410-24.
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Product Notes
The Hippuristanol (Catalog #AAA3606008) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Hippuristanol, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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