Structure
HC-070, inhibitor
HC-070
Purity
98.00%
Synonyms
HC-070; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 62.5mg/mL (131.49mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H20Cl2N4O4
SMILES
O=C(N1CCCO)N(C)C2=C(N(CC3=CC=C(Cl)C=C3)C(OC4=CC=CC(Cl)=C4)=N2)C1=O
CAS Number
1628291-95-1
Target & IC50
hTRPC5, cell assay: ic50 9.3nM
hTRPC4, cell assay: ic50 46nM
hTRPC4, cell assay: ic50 46nM
In Vitro
HC-070 (1mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. HC-070 (1mg/kg, p.o.) affects mice with increased evoked anxiety (CCK-4) but shows no effects in the absence of CCK-4. HC-070 (0.3, 1 or 3mg/kg, p.o.) reduces anxiety in a standard EPM (more light/high anxiety). HC-070 (0.3, 1, 3, 10mg/kg, p.o.) also reduces the time of immobility in a tail suspension test but does not impact locomotor activity in mice. HC-070 (1, 3, 10mg/kg, p.o.) causes a reduction in marble-burying behavior [1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for HC-070, inhibitor
HC-070 is a TRPC4/TRPC5 antagonist (IC50s: 9.3nM and 46nM for hTRPC5 and hTRPC4 in cells).
References
Just S, et al. treatment,with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225.
Just S, et al. treatment,with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225.
Just S, et al. treatment,with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225.
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Product Notes
The HC-070 (Catalog #AAA5754950) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HC-070, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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