Testing Data
GSK461364, inhibitor
GSK461364
Synonyms
GSK461364; inhibitor
Solubility
DMSO >=10 mg/mL - Water <1 mg/mL - Ethanol >=63 mg/mL
Formula
C27H28F3N5O2S
CAS Number
929095-18-1
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for GSK461364, inhibitor
GSK 461364 is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM. GSK461364 is an ATP-competitive inhibitor of Plk1 and forms a rapidly reversible complex with Plk1. It has a 400-fold greater potency for Plk1 than for Plk2 and Plk3. It is > 100-fold selective with respect to PLk2, PLK3, and 48 other kinases tested. Treatment of 120 cell lines with GSK-461364 led to growth inhibition with an IC50 of < 100 nM in over 90% cases, with a net cytostatic response in about 40% and net cell death in 45% of cell lines tested. Interestingly, it caused dose-dependent mitotic arrest in Colo205 xenografts in vivo. [1][2]
Product Categories/Family for GSK461364, inhibitor
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Product Notes
The GSK461364 (Catalog #AAA8506485) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK461364, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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