Structure
EZM 2302, Inhibitor
EZM 2302
Purity
99.5% (HPLC)
Synonyms
EZM 2302; GSK 3359088; GSK3359088; EZM2302; inhibitor
Purity/Purification
99.5% (HPLC)
Suitability
100mM in DMSO
Target
HMTase
Receptor
HMTase
Chemical Name
methyl(R)-2-(2-(2-chloro-5-(2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3, 5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2, 7-diazaspiro[3.5]nonane-7-carboxylate
SMILES
O=C(N(CC1)CCC21CN(C3=NC(C4=CC(OC[C@H](O)CNC)=CC=C4Cl)=NC(C5=C(C)ON=C5C)=C3C)C2)OC
Molecular Formula
C29H37ClN6O5
CAS Number
1628830-21-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EZM 2302, inhibitor
EZM 2302 (EZM2302, GSK 3359088) is a potent, selective, orally available arginine methyltransferase CARM1 inhibitor with IC50 of 6nM, with broad selectivity against other HMTases; demonstrates in vitro anti-proliferative activity consistent with specific methyl mark inhibition with IC50 of
Product Categories/Family for EZM 2302, inhibitor
References
1. Drew AE, et al. Sci Rep. 2017 Dec 21; 7 (1):17993.
2. Greenblatt SM, et al. Cancer Cell. 2018 Jun 11; 33 (6):1111-1127.e5.
2. Greenblatt SM, et al. Cancer Cell. 2018 Jun 11; 33 (6):1111-1127.e5.
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Product Notes
The EZM 2302 (Catalog #AAA3602435) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EZM 2302, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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