EPZ020411 2HCl, Inhibitor | EPZ020411, inhibitor
EPZ020411 2HCl
Purity
98.00%
Synonyms
EPZ020411 2HCl; EPZ020411; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 100mg/ml (193.98mM)
Ethanol: 100mg/ml (193.98mM)
Water: 81mg/ml (157.12mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Ethanol: 100mg/ml (193.98mM)
Water: 81mg/ml (157.12mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C25H40Cl2N4O3
SMILES
Cl.Cl.CNCCN(C)CC1=C[NH]N=C1C2=CC=C(OC3CC(C3)OCCC4CCOCC4)C=C2
CAS Number
2070015-25-5
Target & IC50
PRMT1: ic50 119nM
PRMT6: ic50 10nM
PRMT6: ic50 10nM
Cell Research
Cell lines: A375 cells. Concentrations: 0-20uM. Incubation Time: 48 hours. Method: A375 (CRL-1619) cells are cultured in DMEM with 10% (vol/vol) FBS. PRMT6 is cloned into EcoRI and BamHI sites of a pcDNA4 HisMAX_A plasmid. According to procedures recommended by the manufacturer, transfection of his-tagged PRMT6 or vector control is carried out using Lipofectamine LTX and Plus reagent. Cells are seeded at 200,000cells/well in 6-well plates. The second day, the cells are concurrently transfected and treated with compound in 0.25% DMSO. Cells are incubated in the presence compound at 20uM and collected after 48 hours treatment
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for EPZ020411, inhibitor
EPZ020411 is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10nM.
Product Categories/Family for EPZ020411, inhibitor
References
Mitchell LH, et al. ACS Med Chem Lett. 2015, 6(6):655-9.
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Product Notes
The EPZ020411 (Catalog #AAA5756844) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EPZ020411 2HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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