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Structure

Elenbecestat, Inhibitor

Elenbecestat

Purity
98.00%
Synonyms
Elenbecestat; E2609; inhibitor
Ordering
For Research Use Only!
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 250mg/mL (571.51mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H18F3N5O2S
SMILES
FC1=CC=C(NC(C2=NC=C(C(F)F)N=C2)=O)C=C1[C@@]3(N=C(N)SC4)[C@@]4([H])[C@@H](C)OC3
CAS Number
1388651-30-6
Target & IC50
BACE-1
In Vitro
E2609 (0.3-30mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates.E2609 displays the plasma half-life of 12-16 hours after once daily dosing.
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Structure

Structure
Related Product Information for Elenbecestat, inhibitor
Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment,of Alzheimer's disease.
References
Kumar D, et al.Secretase inhibitors for the treatment,of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452.
Kumar D, et al.Secretase inhibitors for the treatment,of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452.
A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer's & Dementia, 8(4), P224.
A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer's & Dementia, 8(4), P224.

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Product Notes

The Elenbecestat (Catalog #AAA5753082) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Elenbecestat, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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