Structure
EDO-S101, Inhibitor
EDO-S101
Purity
>98% (HPLC)
Synonyms
EDO-S101; EDO-S 101; Tinostamustine; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
HDAC
Receptor
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Chemical Name
1H-Benzimidazole-2-heptanamide, 5-[bis(2-chloroethyl)amino]-N-hydroxy-1-methyl
SMILES
CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCCCCC(=O)NO
Molecular Formula
C19H28Cl2N4O2
CAS Number
1236199-60-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EDO-S101, inhibitor
EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat; displays potent activity in vitro in MM cell lines (IC50=1.6-4.8uM) and ex vivo in cells isolated from MM patients; shows activity in CB17-SCID murine plasmacytoma model and in de novo Vk*MYC mice, also is the only drug with single-agent activity in the multidrug resistant Vk12653 murine model. Blood Cancer
Product Categories/Family for EDO-S101, inhibitor
References
1. Mehrling T, et al. Anticancer Agents Med Chem. 2016; 16 (1):20-8.
2. Lopez-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20; 10 (1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28; 7 (7):e589.
2. Lopez-Iglesias AA, et al. J Hematol Oncol. 2017 Jun 20; 10 (1):127.
3. Besse L, et al. Blood Cancer J. 2017 Jul 28; 7 (7):e589.
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Product Notes
The EDO-S101 (Catalog #AAA3600949) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EDO-S101, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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