Structure
Defactinib, Inhibitor
Defactinib
Purity
>98% (HPLC)
Synonyms
Defactinib; VS-6063; VS6063; PF04554878; PF-04554878; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=39mg/mL
Target
FAK
Receptor
FAK
Chemical Name
Benzamide, N-methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]
SMILES
CNC(=O)C1=CC=C(NC2=NC=C(C(NCC3=NC=CN=C3N(C)S(C)(=O)=O)=N2)C(F)(F)F)C=C1
Molecular Formula
C20H21F3N8O3S
CAS Number
1073154-85-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Defactinib, inhibitor
Defactinib (VS-6063, PF-04554878) is a potent, selective and orally active FAK inhibitor, selectively inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines; shows no statistically significant changes in FAK phosphorylation at the other residues (Tyr 576/577, Tyr 925, or Tyr 861), also inhibits Pyk2 Tyr402 phosphorylation in HeyA8 cells; markedly decreases proliferation and increases apoptosis combined with paclitaxel, reduces levels of AKT and YB-1 in taxane-resistant cell lines; significantly reduces tumor growth, synergized with the mTOR inhibitor everolimus in xenograft models of pancreatic tumor. Lung Cancer Phase 2 Clinical
Product Categories/Family for Defactinib, inhibitor
References
1. Kang Y, et al. J Natl Cancer Inst. 2013 Oct 2; 105 (19):1485-95.
2. Shimizu T, et al. Cancer Chemother Pharmacol. 2016 May; 77 (5):997-1003.
3. Jones SF, et al. Invest New Drugs. 2015 Oct; 33 (5):1100-7.
4. Franois RA, et al. J Natl Cancer Inst. 2015 May 12; 107 (8). pii: djv123.
2. Shimizu T, et al. Cancer Chemother Pharmacol. 2016 May; 77 (5):997-1003.
3. Jones SF, et al. Invest New Drugs. 2015 Oct; 33 (5):1100-7.
4. Franois RA, et al. J Natl Cancer Inst. 2015 May 12; 107 (8). pii: djv123.
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Product Notes
The Defactinib (Catalog #AAA3600299) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Defactinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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