Dasatinib hydrochloride, Inhibitor
Dasatinib hydrochloride
Purity
98.00%
Synonyms
Dasatinib hydrochloride; BMS-354825 HCl; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 100mg/ml (190.67mM)
Water: 42mg/ml (80.08mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Water: 42mg/ml (80.08mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H27Cl2N7O2S
SMILES
Cl.CC1=NC(=CC(=N1)NC2=NC=C(S2)C(=O)NC3=C(C)C=CC=C3Cl)N4CCN(CCO)CC4
CAS Number
854001-07-3
Target & IC50
Abl: ic50 0.6nM
c-Kit (D816V): ic50 37nM
c-Kit (wt): ic50 79nM
Src: ic50 0.8nM
c-Kit (D816V): ic50 37nM
c-Kit (wt): ic50 79nM
Src: ic50 0.8nM
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Dasatinib hydrochloride, inhibitor
Dasatinib hydrochloride is a highly ATP competitive, potent, orally active inhibitor of dual Src/Bcr-Abl(with Ki values of 16 pM and 30 pM for Src and Bcr-Abl, respectively), and has potent antitumor activity.
Product Categories/Family for Dasatinib hydrochloride, inhibitor
References
O'Hare T, et al. Cancer Res. 2005, 65(11):4500-5.
Shah NP, et al. Blood. 2006, 108(1):286-91.
Shah NP, et al. Blood. 2006, 108(1):286-91.
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Product Notes
The Dasatinib hydrochloride (Catalog #AAA5756826) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dasatinib hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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