Conantokin G, Inhibitor
Conantokin G
Purity
98.00%
Synonyms
Conantokin G; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
Water: 1mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C88H138N26O44
CAS Number
93438-65-4
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Conantokin G, inhibitor
GluN2B (formally NR2B) selective, competitive antagonist of thenMDA receptor. BlocksnMDA-evoked current in mouse cortical neurons (IC50 = 480nM); also inhibitsnMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300nM). Exhibits neuroprotective properties in vivo and in vitro.
References
Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID:
Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID:
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID:
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID:
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp. Ther. 294 378 PMID:
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp. Ther. 294 378 PMID:
Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614 PMID:
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID:
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to metha. by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55 PMID:
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp. Ther. 294 378 PMID:
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp. Ther. 294 378 PMID:
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Product Notes
The Conantokin G (Catalog #AAA5764055) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Conantokin G, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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