Cilengitide, Inhibitor

Cilengitide

Cat. Num. AAA384670

• Purity: >98%
• Synonyms: Cilengitide; EMD 12197; EMD-85189; EMD-121974; NSC-707544; D03497; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 16.99 mL (1 mg); 84.94 mL (5 mg); 169.88mL (10 mg); 0.5 mM: 3.4 mL (1 mg); 16.99 mL (5 mg); 33.98 mL (10 mg); 1 mM: 1.7 mL (1 mg); 8.49 mL (5 mg); 16.99 mL (10 mg); 5 mM: 0.34 mL (1 mg); 1.7 mL (5 mg); 3.4 mL (10 mg) (varies by lot)

• CAS Number: 188968-51-6
• Formula: C27H40N8O7
• SMILES: CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N
• In Vivo Solvent: 30% propylene glycol, 5% Tween 80, 65% D5W
• Solubility (DMSO): 100 mg/mL (169.87 mM)
• Solubility (Ethanol): <1 mg/mL (<1 mM)
• Solubility (in vivo): 30 mg/mL
• Solubility (Water): 8 mg/mL (13.59 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for Cilengitide, inhibitor

Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.

References

Rosalie Richards, .et al. 4D imaging and analysis of multicellular tumour spheroid cell migration and invasion, bioRxiv, 2018, 15 Oct 2018
Hiroki Kanazawa, .et al. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts, PLoS One, 2017, 12(2): e0173051 PMID: 28235037
Yasuda J, .et al. T3 peptide, a fragment of tumstatin, stimulates proliferation and migration of cardiac fibroblasts through activation of Akt signaling pathway, Naunyn Schmiedebergs Arch Pharmacol, 2017, Nov;390(11):1135-1144 PMID: 28785775
Yasuda J, .et al. T3 peptide, an active fragment of tumstatin, inhibits H2O2-induced apoptosis in H9c2 cardiomyoblasts, Eur J Pharmacol, 2017, Jul 15;807:64-70 PMID: 28457922
Hsian-Yu Wang, .et al. Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses, Onco Targets Ther, 2016, 9: 2961-2973 PMID: 27284246