Structure
CID-1067700, inhibitor
CID-1067700
Purity
98.00%
Synonyms
CID-1067700; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 68mg/mL (174mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C18H18N2O4S2
SMILES
CC1(C)Cc2c(sc(NC(=S)NC(=O)c3ccccc3)c2C(=O)O)CO1
CAS Number
314042-01-8
Target & IC50
Rab7: ic50 13nM
In Vitro
CID-1067700 binds the nucleotide binding pocket of Rab7 with a Ki value of 13nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21nM, respectively[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for CID-1067700, inhibitor
CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13nM).
Product Categories/Family for CID-1067700, inhibitor
References
Agola J O, Hong L, Surviladze Z, et al. A Competitive Nucleotide Binding Inhibitor:, In Vitro, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108.
Agola J O, Hong L, Surviladze Z, et al. A Competitive Nucleotide Binding Inhibitor:, In Vitro, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. ä¸-A›½è¯ç†A-¦æŠ¥:è‹+/-æ-‡ç‰ˆ, 2019(6):724-736.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. 2019(6):724-736.
Lam T, et al. Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus. J Immunol. 2016 Nov 15;197(10):3792-3805.
Agola J O, Hong L, Surviladze Z, et al. A Competitive Nucleotide Binding Inhibitor:, In Vitro, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. ä¸-A›½è¯ç†A-¦æŠ¥:è‹+/-æ-‡ç‰ˆ, 2019(6):724-736.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. 2019(6):724-736.
Lam T, et al. Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus. J Immunol. 2016 Nov 15;197(10):3792-3805.
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Product Notes
The CID-1067700 (Catalog #AAA5758446) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CID-1067700, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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