Chebulic acid, Inhibitor
Chebulic acid
Purity
98.00%
Synonyms
Chebulic acid; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 260mg/mL (729.85mM)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C14H12O11
SMILES
OC(C[C@@H]([C@H]([C@@H](C(O)=O)O1)c(c(O)c(c(O)c2)O)c2C1=O)C(O)=O)=O
CAS Number
23725-05-5
Target & IC50
VEGFR
ROS
ROS
In Vitro
chebulic acid prevents the glycer-AGEs-induced ROS formation of LX-2 cells and collagen accumulation by ERK-phosphorylation-mediated Nrf2 nuclear translocation, which causes upregulation of antioxidant protein production[2].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for Chebulic acid, inhibitor
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits the formation of AGEs.It has effects against the progression of AGE-induced endothelial cell dysfunction,may constitute a promising intervention agent against diabetic vascular complications
Product Categories/Family for Chebulic acid, inhibitor
References
Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24.
Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24.
Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction.J Ethnopharmacol. 2010 Oct 5;131(3):567-74.
Koo Y C, Pyo M C, Nam M H, et al. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway.[J]. Toxicology in Vitro, 2016, 34:8-15.
Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007 Mar;81(3):211-8. Epub 2006 Aug 24.
Effects of chebulic acid on advanced glycation endproducts-induced collagen cross-links. Biol Pharm Bull. 2014;37(7):1162-7. Epub 2014 Apr 24.
Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction.J Ethnopharmacol. 2010 Oct 5;131(3):567-74.
Koo Y C, Pyo M C, Nam M H, et al. Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway.[J]. Toxicology in Vitro, 2016, 34:8-15.
Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol. 2007 Mar;81(3):211-8. Epub 2006 Aug 24.
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Product Notes
The Chebulic acid (Catalog #AAA5759792) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Chebulic acid, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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