Chemical Structure
CA-074 Methyl Ester, Inhibitor
CA-074 Methyl Ester
Purity
>98%
Synonyms
CA-074 Methyl Ester; CA-074 Me; inhibitor
Purity/Purification
>98%
Formula
C19H31N3O6
Smiles
CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC
Biological Activity
CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
CAS No
147859-80-1
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
Store at -20°C.
Chemical Structure
Chemical Structure
Preparing Stock Solutions
(The data below is based on the product molecular weight 397.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.)
Preparing Stock Solutions
(The data below is based on the product molecular weight 397.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.)
Related Product Information for CA-074 Methyl Ester, inhibitor
CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
References
Ming Sun, .et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells, J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546
Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546
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Product Notes
The CA-074 Methyl Ester (Catalog #AAA384430) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CA-074 Methyl Ester, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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