Structure
Pexmetinib, Inhibitor
Pexmetinib
Purity
>98% (HPLC)
Synonyms
Pexmetinib; ARRY-614; ARRY614; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 93mg/mL (167.1mM)
Ethanol: 93mg/mL (167.1mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: 93mg/mL (167.1mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Angiopoietin Receptor
Receptor
p38MAPK
Chemical Name
1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea
SMILES
O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
Molecular Formula
C31H33FN6O3
CAS Number
945614-12-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Pexmetinib, inhibitor
Pexmetinib (ARRY-614) is a potent, orally active, dual Tie-2/p38 MAPK inhibitor with IC50 of 1, 26 and 35nM for Tie-2, p38alpha and p38beta, respectively; demonstrates in vitro mechanistic models (Angpt-1 or anisomycin-stimulated HUVEC) as well as functional readouts (LPS-induced TNF-alpha release from human PBMCs) with IC50 of 2282nM and 172nM for Tie2 and p38, respectively; abrogates cytokine mediated myelosuppresive effects in hematopoietic cells; inhibits leukemic cell proliferation and stimulates hematopoietic activity in MDS; inhibits LPS-induced TNF-alpha release) murine models. Blood Cancer Phase 1 Discontinued
Product Categories/Family for Pexmetinib, inhibitor
References
1. Bachegowda L, et al. Cancer Res. 2016 Aug 15; 76 (16):4841-4849.
2. Garcia-Manero G, et al. Clin Cancer Res. 2015 Mar 1; 21 (5):985-94.
3. Wollenberg LA, et al. Clin Pharmacol. 2015 Sep 30; 7:87-95.
2. Garcia-Manero G, et al. Clin Cancer Res. 2015 Mar 1; 21 (5):985-94.
3. Wollenberg LA, et al. Clin Pharmacol. 2015 Sep 30; 7:87-95.
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Product Notes
The Pexmetinib (Catalog #AAA3606768) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pexmetinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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