Chemical Structure
Bardoxolone methyl (RTA 402), Inhibitor
Bardoxolone methyl (RTA 402)
Purity
>98%
Synonyms
Bardoxolone methyl (RTA 402); NSC 713200; CDDO-methyl ester; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 19.77 mL (1 mg); 98.87 mL (5 mg); 197.75mL (10 mg)
0.5 mM: 3.95 mL (1 mg); 19.77 mL (5 mg); 39.55 mL (10 mg)
1 mM: 1.98 mL (1 mg); 9.89 mL (5 mg); 19.77 mL (10 mg)
5 mM: 0.4 mL (1 mg); 1.98 mL (5 mg); 3.95 mL (10 mg) (varies by lot)
0.5 mM: 3.95 mL (1 mg); 19.77 mL (5 mg); 39.55 mL (10 mg)
1 mM: 1.98 mL (1 mg); 9.89 mL (5 mg); 19.77 mL (10 mg)
5 mM: 0.4 mL (1 mg); 1.98 mL (5 mg); 3.95 mL (10 mg) (varies by lot)
CAS Number
218600-53-4
Formula
C32H43NO4
SMILES
C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
Actions
Inhibitor
In Vivo Solvent
1% DMSO/30% polyethylene glycol/1% Tween 80
Solubility (DMSO)
21 mg/mL (41.52 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
<1 mg/mL (<1 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for Bardoxolone methyl (RTA 402), inhibitor
Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
References
Nakamura S, .et al. Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability, Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952
Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614
Hisamichi M, .et al. Role of bardoxolone methyl, a nuclear factor erythroid 2-related factor 2 activator, in aldosterone- and salt-induced renal injury, Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980
Takahiko Imai, .et al. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation, Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917
Takagi T, .et al. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Free Radic Biol Med., 2014, 72:124-33 PMID: 24746614
Similar Products
Product Notes
The Bardoxolone methyl (RTA 402) (Catalog #AAA385825) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Bardoxolone methyl (RTA 402), Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
