Structure
ASP 8477, Inhibitor
ASP 8477
Purity
>98% (HPLC)
Synonyms
ASP 8477; ASP8477; ASP-8477; inhibitor
Purity/Purification
>98% (HPLC)
Target
FAAH
Receptor
FAAH
Chemical Name
3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate
Molecular Formula
C18H19N3O3
CAS Number
906737-25-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ASP 8477, inhibitor
A novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively; displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL; elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p. O). Pain Phase 2 Discontinued
Product Categories/Family for ASP 8477, inhibitor
References
1. Watabiki T, et al. Eur J Pharmacol. 2017 Nov 15; 815:42-48.
2. Bradford D, et al. Pain Med. 2017 Dec 1; 18 (12):2388-2400.
2. Bradford D, et al. Pain Med. 2017 Dec 1; 18 (12):2388-2400.
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Product Notes
The ASP 8477 (Catalog #AAA3606510) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ASP 8477, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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