Structure

Aplaviroc hydrochloride, Inhibitor

Aplaviroc hydrochloride

Purity

>98% (HPLC)

Synonyms

Aplaviroc hydrochloride; AK-602; GW 873140; ONO-4128; GSK-873140; inhibitor

Ordering

Purity/Purification

>98% (HPLC)

Target

Chemokine Receptor

Receptor

Chemokine Receptor

Chemical Name

4-[4-[[(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2, 5-dioxo-1, 4, 9-triazaspiro[5.5]undecan-9-yl]methyl]phenoxy]benzoic acid hydrochloride

SMILES

CCCCN1C(=O)C(NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)C(C5CCCCC5)O.Cl

Molecular Formula

C33H44ClN3O6

CAS Number

461023-63-2

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for Aplaviroc hydrochloride, inhibitor

Aplaviroc (GSK-873140; GW 873140; AK-602; ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6; blocks the calcium response effects of CCR5 activation by CCL5, and potently blocks in vitro the infection of R5-tropic HIV-1 (R5-HIV-1) at subnanomolar IC50. HIV Infection Phase 3 Discontinued

Product Categories/Family for Aplaviroc hydrochloride, inhibitor

HIV Infection; GPCR/G Protein; Infection

References

1. Watson C, et al. Mol Pharmacol. 2005 Apr; 67 (4):1268-82.
2. Lalezari J, et al. AIDS. 2005 Sep 23; 19 (14):1443-8.
3. Adkison KK, et al. Antimicrob Agents Chemother. 2005 Jul; 49 (7):2802-6.
4. Nakata H, et al. Antimicrob Agents Chemother. 2008 Jun; 52 (6):2111-9.

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Product Notes

The Aplaviroc hydrochloride (Catalog #AAA3604550) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Aplaviroc hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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Aplaviroc hydrochloride, Inhibitor