Structure
Anacetrapib, Inhibitor
Anacetrapib
Purity
>98% (HPLC)
Synonyms
Anacetrapib; MK 0859; MK-0859; MK0859; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CETP
Receptor
MutantCETP (C13S); rhCETP
Chemical Name
2-Oxazolidinone, 5-[3, 5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1, 1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S, 5R)
SMILES
O=C1O[C@H](C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)[C@H](C)N1CC3=CC(C(F)(F)F)=CC=C3C4=CC(C(C)C)=C(F)C=C4OC
Molecular Formula
C30H25F10NO3
CAS Number
875446-37-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Anacetrapib, inhibitor
Anacetrapib (MK 0859) is a potent, orally active cholesteryl ester transfer protein (CETP) inhibitor with IC50 of 7.9nM and 11.8nM for rhCETP and C13S CETP mutant, respectively; inhibits CETP-mediated cholesterol exchange, resulting in elevated HDL-cholesterol levels and reductions in LDL-cholesterol levels, demonstrates potential to treat elevated cholesterol levels in an effort prevent cardiovascular disease. Atherosclerosis Phase 3 Clinical
Product Categories/Family for Anacetrapib, inhibitor
References
1. Krishna R, et al. Lancet. 2007 Dec 8; 370 (9603):1907-14.
2. Vergeer M, et al. Nat Clin Pract Cardiovasc Med. 2008 Jun; 5 (6):302-3.
3. Cannon CP, et al. Am Heart J. 2009 Oct; 158 (4):513-519.e3.
4. Niesor EJ, et al. J Lipid Res. 2010 Dec; 51 (12):3443-54.
2. Vergeer M, et al. Nat Clin Pract Cardiovasc Med. 2008 Jun; 5 (6):302-3.
3. Cannon CP, et al. Am Heart J. 2009 Oct; 158 (4):513-519.e3.
4. Niesor EJ, et al. J Lipid Res. 2010 Dec; 51 (12):3443-54.
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Product Notes
The Anacetrapib (Catalog #AAA3606357) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Anacetrapib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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