ALK-IN-1 (Brigatinib analog, AP26113 analog), Inhibitor

ALK-IN-1 (Brigatinib analog, AP26113 analog)

Cat. Num. AAA384207

• Purity: >98%
• Synonyms: ALK-IN-1 (Brigatinib analog; AP26113 analog); AP-26113; inhibitor

• Purity/Purification: >98%
• Form/Format: Powder
• Concentration: 0.1 mM: 18.9 mL (1 mg); 94.52 mL (5 mg); 189.03mL (10 mg); 0.5 mM: 3.78 mL (1 mg); 18.9 mL (5 mg); 37.81 mL (10 mg); 1 mM: 1.89 mL (1 mg); 9.45 mL (5 mg); 18.9 mL (10 mg); 5 mM: 0.38 mL (1 mg); 1.89 mL (5 mg); 3.78 mL (10 mg) (varies by lot)

• CAS Number: 1197958-12-5
• Formula: C26H34ClN6O2P
• SMILES: CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC
• Actions: Inhibitor
• In Vivo Solvent: NMP/polyethylene glycol 300 (10/90, v/v)
• Solubility (DMSO): 45 mg/mL (85.06 mM)
• Solubility (Ethanol): 106 mg/mL (200.37 mM)
• Solubility (in vivo): 30 mg/mL
• Solubility (Water): <1 mg/mL (<1 mM)
• Availability: We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
• Preparation and Storage: at -20 degree C 3 years Powder

Chemical Structure

Related Product Information for ALK-IN-1 (Brigatinib analog, AP26113 analog), inhibitor

AP26113 is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line. In a panel of EML4-ALK or NPM-ALK-positive cell lines, AP26113 has IC50 values of 4-31 nM. AP26113 is effective against sensitive and resistant H3122 cells, reducing cell growth, suppressing ALK phosphorylation, and inducing apoptosis. In Ba/F3 cells expressing native or mutant EML4-ALK, AP26113 was active at IC50s of 10 and 24 nM, respectively.