Structure
AHU377 calcium salt, Inhibitor
AHU377 calcium salt
Purity
>98% (HPLC)
Synonyms
AHU377 calcium salt; AHU-377 (hemicalcium salt); inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=54mg/mL (125.43mM)
Target
c-Met/HGFR
Receptor
Neprilysin
SMILES
CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(cc1)c1ccccc1)NC(=O)CCC(=O)[O-].[Ca+2].CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(cc1)c1ccccc1)NC(=O)CCC(=O)[O-]
Molecular Formula
C48H56CaN2O10
CAS Number
1369773-39-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AHU377 calcium salt, inhibitor
AHU-377 hemicalcium salt is a potent NEP inhibitor with an IC50 of 5nM. AHU-377 is a component of the heart failure medicine LCZ696. AHU377 is a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan (Item No. 14178) are used to treat hypertension and heart failure.
Product Categories/Family for AHU377 calcium salt, inhibitor
References
1.Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril.Sci Rep. 2016 Jun 15; 6:27909.
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Product Notes
The AHU377 calcium salt (Catalog #AAA3607256) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AHU377 calcium salt, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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