Structure
A12B4C3, Inhibitor
A12B4C3
Purity
>98% (HPLC)
Synonyms
A12B4C3; hPNKP inhibitor A12B4C3; inhibitor
Purity/Purification
>98% (HPLC)
Target
DNA Repair Protein
Receptor
DNA Repair Protein
Chemical Name
4a, 7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3, 4-b]pyridine-5, 7(2H, 6H)-dione
SMILES
O=C1N(C2=CC=CC=C2)C(C3C1C=CC(C(O)CCCCCCCCCC)N3NC4=CC=C([N+]([O-])=O)C=C4)=O
Molecular Formula
C30H38N4O5
CAS Number
1005129-80-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for A12B4C3, inhibitor
A12B4C3 (hPNKP inhibitor A12B4C3) is a specific, noncompetitive inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (hPNKP) with C50 of 60nM, displays no inhibition of calcineurin and protein phosphatase-1 or APTX; A12B4C3 enhanced the radiosensitivity of human A549 lung carcinoma and MDA-MB-231 breast adenocarcinoma cells, failed to increase the radiosensitivity of the hPNKP-depleted cells; A12B4C3 also inhibits the repair of DNA single and double strand breaks following exposure of cells to ionizing radiation, but does not inhibit two other key strand-break repair enzymes, DNA polymerase beta or DNA ligase III.
Product Categories/Family for A12B4C3, inhibitor
References
1. Freschauf GK, et al. Cancer Res. 2009 Oct 1; 69 (19):7739-46.
2. Freschauf GK, et al. J Biol Chem. 2010 Jan 22; 285 (4):2351-60.
3. Zereshkian A, et al. Nucl Med Biol. 2014 May-Jun; 41 (5):377-83.
2. Freschauf GK, et al. J Biol Chem. 2010 Jan 22; 285 (4):2351-60.
3. Zereshkian A, et al. Nucl Med Biol. 2014 May-Jun; 41 (5):377-83.
Similar Products
Product Notes
The A12B4C3 (Catalog #AAA3600040) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "A12B4C3, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
