Structure
4EGI-1, Inhibitor
4EGI-1
Purity
>98% (HPLC)
Synonyms
4EGI-1; eIF4E/eIF4G Interaction Inhibitor; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=35mg/mL
Target
eIF
Receptor
eIF-4E/eIF-4G
Chemical Name
Benzenepropanoic acid, alpha-[2-[4-(3, 4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro
SMILES
O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
Molecular Formula
C18H12Cl2N4O4S
CAS Number
315706-13-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for 4EGI-1, inhibitor
4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25uM (binding to eIF4E); disrupts eIF4E/eIF4G association and inhibits cap-dependent translation; inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.
Product Categories/Family for 4EGI-1, inhibitor
References
1. Moerke NJ, et al. Cell. 2007 Jan 26; 128 (2):257-67.
2. Wang W, et al. Oncotarget. 2016 Apr 19; 7 (16):21728-41.
3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5; 111 (31):E3187-95.
2. Wang W, et al. Oncotarget. 2016 Apr 19; 7 (16):21728-41.
3. Papadopoulos E, et al. Proc Natl Acad Sci U S A. 2014 Aug 5; 111 (31):E3187-95.
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Product Notes
The 4EGI-1 (Catalog #AAA3604028) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "4EGI-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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