4beta-Hydroxywithanolide E, Inhibitor
4beta-Hydroxywithanolide E
Purity
98.00%
Synonyms
4beta-Hydroxywithanolide E; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C28H38O8
CAS Number
54334-04-2
Target & IC50
COX
HSP90
NF-kappaB
p21
PARP
HSP90
NF-kappaB
p21
PARP
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Related Product Information for 4beta-Hydroxywithanolide E, inhibitor
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by modulating splicing factors and histone modifications.4bHWE is a useful natural anti-inflammatory compound to attenuate progression of diabetes and obesity, it decreases inflammatory responses by inhibiting the NF-kappaB signaling in diabetic mouse adipose tissue, it also can improve impaired glucose tolerance.
Product Categories/Family for 4beta-Hydroxywithanolide E, inhibitor
References
4beta-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells. Sci Rep. 2017 Aug 4;7(1):7290.
Non-homologous end joining pathway is the major route of protection against 4beta-hydroxywithanolide E-induced DNA damage in MCF-7 cells. Food Chem Toxicol. 2014 Mar;65:205-12.
Non-homologous end joining pathway is the major route of protection against 4beta-hydroxywithanolide E-induced DNA damage in MCF-7 cells. Food Chem Toxicol. 2014 Mar;65:205-12.
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Product Notes
The 4beta-Hydroxywithanolide E (Catalog #AAA5761591) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "4beta-Hydroxywithanolide E, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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