Structure
2-hydroxy Flutamide, Inhibitor
2-hydroxy Flutamide
Purity
98.53%
Synonyms
2-hydroxy Flutamide; inhibitor
Purity/Purification
98.53%
Form/Format
Solid. Powder
Solubility
DMSO: 25mg/mL (85.5mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C11H11F3N2O4
SMILES
CC(C)(O)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
CAS Number
52806-53-8
Target & IC50
Androgen Receptor
In Vitro
The pharmacologically active metabolite 2-hydroxy-flutamide, this principle metabolite increased CYP3A metabolism of midazolam in human microsomes (30%) and hepatocytes (110%)[1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for 2-hydroxy Flutamide, inhibitor
2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment,of prostate cancer
Product Categories/Family for 2-hydroxy Flutamide, inhibitor
References
Blobaum A L, Byers F W, Bridges T M, et al. A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2015, 43(11):1718.
Blobaum A L, Byers F W, Bridges T M, et al. A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2015, 43(11):1718.
Gao W, Kim J, Dalton J T. Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands[J]. Pharmaceutical Research, 2006, 23(8):1641-1658.
Gao W, Kim J, Dalton J T. Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands[J]. Pharmaceutical Research, 2006, 23(8):1641-1658.
Blobaum A L, Byers F W, Bridges T M, et al. A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo.[J]. Drug Metabolism & Disposition the Biological Fate of Chemicals, 2015, 43(11):1718.
Gao W, Kim J, Dalton J T. Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands[J]. Pharmaceutical Research, 2006, 23(8):1641-1658.
Gao W, Kim J, Dalton J T. Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands[J]. Pharmaceutical Research, 2006, 23(8):1641-1658.
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Product Notes
The 2-hydroxy Flutamide (Catalog #AAA5758580) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "2-hydroxy Flutamide, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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