Inositol Monophosphatase Domain Containing 1 Recombinant Protein | IMPAD1 recombinant protein
Recombinant Mouse Inositol Monophosphatase Domain Containing 1
Gene Names
Impad1; Jaws; gPAPP; AA408880; AI451589; AL022796; B230207P20; 1110001C20Rik
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
Inositol Monophosphatase Domain Containing 1; Recombinant Mouse Inositol Monophosphatase Domain Containing 1; IMPAD1 Mouse; Inositol monophosphatase 3; IMP 3; IMPase 3; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident PAP phosphatase; gPAPP; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3 Myo-inositol; Inositol Monophosphatase Domain Containing 1 Mouse Recombinant; IMPAD1 recombinant protein
Host
Sf9 Insect cells
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
Sterile filtered colorless solution.
IMPAD1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
IMPAD1 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Sequence
ADPGRFSLFG LGSEPAAGEA EVASDGGTVD LREMLAVAVL AAERGGDEVRRVRESNVLHE KSKGKTREGA DDKMTSGDVL SNRKMFYLLK TAFPNVQINT EEHVDASDKEVIVWNRKIPE DILKEIAAPK EVPAESVTVW IDPLDATQEY TEDLRKYVTT MVCVAVNGKP VLGVIHKPFS EYTAWAMVDG GSNVKARSSYNEKTPKIIVS RSHAGMVKQV ALQTFGNQTS IIPAGGAGYK VLALLDVPDM TQEKADLYIH VTYIKKWDIC AGNAILKALG GHMTTLNGEEISYTGSDGIE GGLLASIRMN HQALVRKLPD LEKSGHHHHH HH
Sequence Length
356
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Related Product Information for IMPAD1 recombinant protein
Description: IMPAD1 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 332 amino acids (34-356aa) and having a molecular mass of 36.2kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). IMPAD1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction: Inositol monophosphatase 3 (IMPAD1) belongs to the inositol monophosphatase family. IMPAD1 is restricted to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). IMPAD1 gene mutations cause the GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of the IMPAD1 gene is located on the long arm of chromosome 1.
Introduction: Inositol monophosphatase 3 (IMPAD1) belongs to the inositol monophosphatase family. IMPAD1 is restricted to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). IMPAD1 gene mutations cause the GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of the IMPAD1 gene is located on the long arm of chromosome 1.
Product Categories/Family for IMPAD1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,616 Da
NCBI Official Full Name
inositol monophosphatase 3
NCBI Official Synonym Full Names
inositol monophosphatase domain containing 1
NCBI Official Symbol
Impad1
NCBI Official Synonym Symbols
Jaws; gPAPP; AA408880; AI451589; AL022796; B230207P20; 1110001C20Rik
NCBI Protein Information
inositol monophosphatase 3
UniProt Protein Name
Inositol monophosphatase 3
Protein Family
UniProt Gene Name
Impad1
UniProt Synonym Gene Names
Impa3; IMP 3; IMPase 3; Golgi-resident PAP phosphatase; gPAPP
Uniprot Description
IMPAD1: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Defects in IMPAD1 are the cause of chondrodysplasia with joint dislocations GPAPP type (CDP-GPAPP). A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face. Belongs to the inositol monophosphatase family.
Protein type: Cell development/differentiation; EC 3.1.3.25; EC 3.1.3.7; Membrane protein, integral; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 4|4 A1
Cellular Component: cytoplasm; Golgi apparatus; membrane
Molecular Function: 3'-nucleotidase activity; magnesium ion binding
Biological Process: chondrocyte development; chondroitin sulfate metabolic process; embryonic digit morphogenesis; endochondral ossification; post-embryonic development; skeletal development
Research Articles on IMPAD1
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Product Notes
The IMPAD1 impad1 (Catalog #AAA146893) is a Recombinant Protein produced from Sf9 Insect cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ADP GRFSLFG LGSEPAAGEA EVASDGGTVD LREMLAVAVL AAERGGDEVR RVRESNVLHE KSKGKTREGA DDKMTSGDVL SNRKMFYLLK TAFP NVQINT EEHVDASDKE VIVWNRKIPE DILKEIAAPK EVPAESVTVW IDPLDATQEY TEDLRKYVTT MVCVAVNGKP VLGVIHKPFS EYTA WAMVDG GSNVKARSSY NEKTPKIIVS RSHAGMVKQV ALQTFGNQTS IIPAGGAGYK VLALLDVPDM TQEKADLYIH VTYIKKWDIC AGNAILKALG GHMTTLNGEE ISYTGSDGIE GGLLASIRMN HQALVRKLPD LEKSGHH HHH HH. It is sometimes possible for the material contained within the vial of "Inositol Monophosphatase Domain Containing 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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