Human Interleukin-7 ELISA Kit | IL7 elisa kit

Human Interleukin-7 ELISA Kit

Cat. Num. AAA2886996

• Gene Names: IL7; IL-7
• Reactivity: Human
• Synonyms: Interleukin-7; Human Interleukin-7 ELISA Kit; IL-7; IL7; IL7 elisa kit

• Reactivity: Human
• Sequence Length: 177

• Assay Type: Sandwich
• Detection Range: 15.6-1000 pg/mL
• Sensitivity: 7.9 pg/mL
• Intra-Assay CV: <=6.8%
• Inter-Assay CV: <=9.6%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4504677
• NCBI GeneID: 3574
• NCBI Accession #: NP_000871.1
• NCBI GenBank Nucleotide #: NM_000880.3
• UniProt Accession #: P13232; Q5FBY5; Q5FBY9; A0N0L3
• Molecular Weight: 7,687 Da
• NCBI Official Full Name: interleukin-7 isoform 1
• NCBI Official Synonym Full Names: interleukin 7
• NCBI Official Symbol: IL7
• NCBI Official Synonym Symbols: IL-7
• NCBI Protein Information: interleukin-7
• UniProt Protein Name: Interleukin-7
• Protein Family: Interleukin
• UniProt Gene Name: IL7
• UniProt Synonym Gene Names: IL-7
• UniProt Entry Name: IL7_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Uniprot Description

IL7: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell cycle regulation; Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 8q12-q13

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-7 receptor binding; protein binding

Biological Process: bone resorption; cell-cell signaling; homeostasis of number of cells within a tissue; humoral immune response; negative regulation of apoptosis; negative regulation of catalytic activity; organ morphogenesis; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of organ growth; positive regulation of T cell differentiation; regulation of gene expression; T cell lineage commitment