Interleukin 6, Chicken Recombinant Protein | IL6R recombinant protein

Interleukin 6, Recombinant, Chicken (IL-6, CHIL-6, Interferon beta 2, IFNB2)

Gene Names

IL6R; gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991

Purity

Purified
~85% by Ni Chelate chromatography

Synonyms

Interleukin 6; Chicken; Recombinant; Chicken (IL-6; CHIL-6; Interferon beta 2; IFNB2); IL6R recombinant protein

Ordering
Cat. Num. AAA650037 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli

Purity/Purification

Purified
~85% by Ni Chelate chromatography

Form/Format

Supplied as a liquid in PBS. Preservative free.

Application Notes

Suitable for use in ELISA, Functional Assays and In vitro Assays.
Dilution: Functional Assays: Induces corticosterone secretion in vivo.
In vitro Assays: Induces proliferation of the IL-6 dependant murine hybridoma cell line 7TD1

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for IL6R recombinant protein

Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine, produced by a wide variety of cells including B lymphocytes, T lymphocytes, monocytes/macrophages, fibroblasts and endothelial cells and plays a major role in the regulation of immune responses, haematopoiesis and the induction of acute phase responses.

Recombinant protein corresponding to chicken IL-6, his-tagged, expressed in E. coli.

Product Categories/Family for IL6R recombinant protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

NCBI GI #

32581

NCBI GeneID

3570

UniProt Accession #

P08887; Q16202; Q53EQ7; Q5FWG2; Q5VZ23; A8KAE8; B2R6V4

Molecular Weight

~23.2kD

NCBI Official Full Name

interleukin-6-receptor

NCBI Official Synonym Full Names

interleukin 6 receptor

NCBI Official Symbol

IL6R

NCBI Official Synonym Symbols

gp80; CD126; IL6RA; IL-6RA; IL-6R-1; MGC104991

NCBI Protein Information

interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; OTTHUMP00000034320; OTTHUMP00000217867; OTTHUMP00000217870; membrane glycoprotein 80; IL-6 receptor subunit alpha

UniProt Protein Name

Interleukin-6 receptor subunit alpha

Protein Family

Interleukin-6 receptor

UniProt Gene Name

IL6R

UniProt Entry Name

IL6RA_HUMAN

NCBI Description

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Uniprot Description

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14

Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST.

Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14.

Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Post-translational modification: A short soluble form may also be released from the membrane by proteolysis.

Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Research Articles on IL6R

1. Circulating sIL-6R and CD4+ IL-6R+ T cells were increased in chronic hepatitis B patients.

Similar Products

IL-6RA Recombinant Protein

Host: Human Cells

Reactivity: n/a

Apps: n/a

Product Notes

The IL6R il6r (Catalog #AAA650037) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. Suitable for use in ELISA, Functional Assays and In vitro Assays. Dilution: Functional Assays: Induces corticosterone secretion in vivo. In vitro Assays: Induces proliferation of the IL-6 dependant murine hybridoma cell line 7TD1. Researchers should empirically determine the suitability of the IL6R il6r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 6, Chicken, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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