CD124 (IL4Ra) Recombinant Protein | CD124 recombinant protein

Human CD124 Recombinant (IL4Ra)

Cat. Num. AAA553069

• Purity: >98%, as determined by SDS-PAGE and HPLC
• Synonyms: CD124 (IL4Ra); Human CD124 Recombinant (IL4Ra); Human CD124 Recombinant (IL4Ra) ; CD124; IL4Ra; IL4R; il-4r; CD124 recombinant protein

• Host: HEk293 Cells
• Purity/Purification: >98%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant CD124 is supplied as a 0.2 um filtered PBS solution, pH7.2.
• Sequence Length: 825

• Domain: Ig-like C2
• Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD124 including a C-terminal 6His tag was expressed in HEK293 cells.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Molecular Weight Note: Recombinant CD124 is a monomer protein consisting of 218 amino acid residue subunits, due to glycosylation migrates as an approximately 43-48 kDa protein on SDS-PAGE.
• Preparation and Storage: Recombinant CD124, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.; ; Avoid repeated freeze/thaw cycles.

Product Categories/Family for CD124 recombinant protein

Receptors CD

NCBI and Uniprot Product Information

• NCBI GI #: 4557669
• NCBI GeneID: 3566
• NCBI Accession #: NP_000409.1
• NCBI GenBank Nucleotide #: NM_000418.3
• UniProt Accession #: P24394; Q96P01; Q9H181; Q9H182; Q9H183; Q9H184; Q9H185; Q9H186; Q9H187; Q9H188; B9EKU8; H3BSY5; Q53EP8
• Molecular Weight: 89,658 Da
• NCBI Official Full Name: interleukin-4 receptor subunit alpha isoform a
• UniProt Protein Name: Interleukin-4 receptor subunit alpha
• UniProt Gene Name: IL4R
• UniProt Synonym Gene Names: IL4RA; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL4-BP
• UniProt Entry Name: IL4RA_HUMAN

NCBI Description

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

Uniprot Description

IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p12.1-p11.2

Cellular Component: extracellular space; integral to plasma membrane; receptor complex

Molecular Function: protein binding; receptor signaling protein activity; interleukin-4 receptor activity

Biological Process: ovulation; positive regulation of T-helper 2 cell differentiation; negative regulation of T-helper 1 cell differentiation; production of molecular mediator of acute inflammatory response; response to estrogen stimulus; immune response; defense response to protozoan; signal transduction; positive regulation of macrophage activation; regulation of cell proliferation

Disease: Ige Responsiveness, Atopic; Human Immunodeficiency Virus Type 1, Susceptibility To