Interleukin-34 ELISA Kit | IL34 elisa kit

Mouse IL-34 PicoKine ELISA Kit

Cat. Num. AAA177550

• Gene Names: Il34; AI593503; 2010004A03Rik
• Reactivity: Mouse. There is no detectable cross-reactivity with other relevant proteins.
• Synonyms: Interleukin-34; Mouse IL-34 PicoKine ELISA Kit; C16orf77; Chromosome 16 open reading frame 77; FPT025; IL 34; IL-34; IL34; IL34_HUMAN; Interleukin 34; Interleukin34; MGC34647; interleukin 34; IL34 elisa kit

• Reactivity: Mouse. There is no detectable cross-reactivity with other relevant proteins.
• Sequence Length: 235

• Samples: Cell culture supernates, serum and plasma (heparin, EDTA)
• Assay Type: Sandwich
• Sensitivity: <10pg/ml
• Immunogen: E.coli, N21-P235
• Intra-Assay Precision: Sample 1: n=16; Mean(pg/ml): 675; Standard deviation: 28.35; CV(%): 4.2 Sample 2: n=16; Mean(pg/ml): 1810; Standard deviation: 66.97; CV(%): 3.7 Sample 3: n=16; Mean(pg/ml): 2944; Standard deviation: 103; CV(%): 3.5
• Inter-Assay Precision: Sample 1: n=24; Mean(pg/ml): 792; Standard deviation: 51.48; CV(%): 6.5 Sample 2: n=24; Mean(pg/ml): 1948; Standard deviation: 103.2; CV(%): 5.3 Sample 3: n=24; Mean(pg/ml): 3107; Standard deviation: 152.2; CV(%): 4.9
• Assay Range: 62.5pg/ml-4000pg/ml
• Preparation and Storage: Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Typical Testing Data/Standard Curve (for reference only)

(Mouse IL-34 PicoKine ELISA Kit standard curve )

Related Product Information for IL34 elisa kit

Description: Sandwich ELISA kit of Quantitative Detection for Mouse IL-34
Background: Interleukin-34, or IL-34 is a protein belonging to a group of cytokines called interleukins. It is mapped to 16q22.1. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. IL-34 is a recently discovered cytokine that acts on tissue resident macrophages and Langerhans cells upon binding the receptor for CSF-1, CSF-1R. It also can promote the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor. In addition, it promotes the development, survival, and function of microglia and Langerhans cells, therefore, this cytokine may predominately function in brain and skin biology.

NCBI and Uniprot Product Information

• NCBI GI #: 205360952
• NCBI GeneID: 76527
• NCBI Accession #: NP_001128572.1
• NCBI GenBank Nucleotide #: NM_001135100.2
• UniProt Accession #: Q8R1R4; Q9D8F2; B2ZC71; B2ZC72
• Molecular Weight: 26,636 Da
• NCBI Official Full Name: interleukin-34 isoform 1
• NCBI Official Synonym Full Names: interleukin 34
• NCBI Official Symbol: Il34
• NCBI Official Synonym Symbols: AI593503; 2010004A03Rik
• NCBI Protein Information: interleukin-34
• UniProt Protein Name: Interleukin-34
• Protein Family: Interleukin
• UniProt Gene Name: Il34
• UniProt Synonym Gene Names: IL-34
• UniProt Entry Name: IL34_MOUSE

Uniprot Description

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Cell cycle regulation; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: immune system process; positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response