Interleukin 31 Recombinant Protein | IL31 recombinant protein

Interleukin 31, Recombinant, Mouse (IL-31)

Cat. Num. AAA650589

• Gene Names: IL31; IL-31
• Purity: Highly Purified; 98% by SDS-PAGE and HPLC analyses.
• Synonyms: Interleukin 31; Recombinant; Mouse (IL-31); IL31 recombinant protein

• Host: E Coli
• Purity/Purification: Highly Purified; 98% by SDS-PAGE and HPLC analyses.
• Form/Format: Supplied as a lyophilized powder from 20mM sodium phosphate, pH 7.5.

• Country of Origin: USA
• Reconstitution: Reconstitute sterile ddH2O to a concentration of 0.1-1mg/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile ddH2O, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for IL31 recombinant protein

IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8kD protein containing 140 amino acid residues.

Product Categories/Family for IL31 recombinant protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 62122911
• NCBI GeneID: 386653
• NCBI Accession #: NP_001014358.1
• NCBI GenBank Nucleotide #: NM_001014336.1
• UniProt Accession #: Q6EBC2; A2RUQ1
• Molecular Weight: 18,205 Da
• NCBI Official Full Name: interleukin-31
• NCBI Official Synonym Full Names: interleukin 31
• NCBI Official Symbol: IL31
• NCBI Official Synonym Symbols: IL-31
• NCBI Protein Information: interleukin-31; OTTHUMP00000239740
• UniProt Protein Name: Interleukin-31
• Protein Family: Interleukin
• UniProt Gene Name: IL31
• UniProt Entry Name: IL31_HUMAN

NCBI Description

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM]

Uniprot Description

Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. Ref.1

Subcellular location: Secreted

Probable.

Tissue specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. Ref.1

Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD). Ref.3 Ref.4