IL2RG recombinant protein

IL2RG, 23-262aa, Human, His tag, Baculovirus

Cat. Num. AAA206116

• Gene Names: IL2RG; P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: IL2RG; 23-262aa; Human; His tag; Baculovirus; Cytokine receptor common subunit gamma; CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; IL2RG recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffer saline (pH 7.4)
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: LNTTILTPNG NEDTTADFFL TTMPTDSLSV STLPLPEVQC FVFNVEYMNC TWNSSSEPQP TNLTLHYWYK NSDNDKVQKC SHYLFSEEIT SGCQLQKKEI HLYQTFVVQL QDPREPRRQA TQMLKLQNLV IPWAPENLTL HKLSESQLEL NWNNRFLNHC LEHLVQYRTD WDHSWTEQSV DYRHKFSLPS VDGQKRYTFR VRSRFNPLCG SAQHWSEWSH PIHWGSNTSK ENPFLFALEA HHHHHH
• Sequence Length: 369

• Applicable Applications for IL2RG recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for IL2RG recombinant protein

IL2RG, also known as Interleukin-2 receptor common subunit gamma, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors. This protein is located on the surface of immature blood-forming cells in bone marrow. One end of the protein resides outside of the cell where it binds to cytokines and the other end of the protein resides in the interior of the cell where it transmits signals to the cell's nucleus. The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes. It also directs the growth and maturation of lymphocyte subtypes. These cells kill viruses, make antibodies, and help regulate the entire immune system. Recombinant human IL2RG, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for IL2RG recombinant protein

Hormones & Cytokines; Immunology

References

Wang X. et al. (2005). Science. 310:1159-1163.; Russell SM. et al. (1993). Science. 262:1880-1883.;

NCBI and Uniprot Product Information

• NCBI GI #: 4557882
• NCBI GeneID: 3561
• NCBI Accession #: NP_000197
• NCBI GenBank Nucleotide #: NM_000206.2
• UniProt Accession #: P31785; Q5FC12
• Molecular Weight: 29.0KDa (246aa) 40-57kDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: cytokine receptor common subunit gamma
• NCBI Official Synonym Full Names: interleukin 2 receptor subunit gamma
• NCBI Official Symbol: IL2RG
• NCBI Official Synonym Symbols: P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1
• NCBI Protein Information: cytokine receptor common subunit gamma
• UniProt Protein Name: Cytokine receptor common subunit gamma
• Protein Family: Cytokine receptor
• UniProt Gene Name: IL2RG
• UniProt Synonym Gene Names: IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG

NCBI Description

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]

Uniprot Description

Common subunit for the receptors for a variety of interleukins.