IL-22/Interleukin-22 Recombinant Protein | IL-22 recombinant protein

Recombinant Human IL-22/Interleukin-22 Protein

Cat. Num. AAA2557230

• Gene Names: IL22; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• Purity: > 95% as determined by reducing SDS-PAGE.
• Synonyms: IL-22/Interleukin-22; Recombinant Human IL-22/Interleukin-22 Protein; Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF; IL-22 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
• Sequence: Ala34-Ile179
• Sequence Length: 179

• Species: Human
• Endotoxin: < 1.0 EU per ug as determined by the LAL method.
• Reconstitution: We recommend that the vial be centrifuged to opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water(66ul) be added to the vial to prepare a stock solution of 0.15mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; Shipping: This product is provided as lyophilized powder which is shipped with blue ice.

SDS-PAGE

Related Product Information for IL-22 recombinant protein

Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

NCBI and Uniprot Product Information

• NCBI GI #: 10092625
• NCBI GeneID: 50616
• NCBI Accession #: NP_065386.1
• NCBI GenBank Nucleotide #: NP_065386.1
• UniProt Accession #: Q9GZX6
• Molecular Weight: Molecular Mass: 17.9kDa; Actual Protein Molecular Mass: 25-35kDa
• NCBI Official Full Name: interleukin-22
• NCBI Official Synonym Full Names: interleukin 22
• NCBI Official Symbol: IL22
• NCBI Official Synonym Symbols: TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
• NCBI Protein Information: interleukin-22
• UniProt Protein Name: Interleukin-22
• UniProt Gene Name: IL22
• UniProt Synonym Gene Names: ILTIF; ZCYTO18; IL-22; IL-TIF
• UniProt Entry Name: IL22_HUMAN

NCBI Description

This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]

Uniprot Description

IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-22 receptor binding; cytokine activity

Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response